Repetitive expanded T-cell receptor clonotypes impart the classic T helper 2 Sézary cell phenotype.
Tony T JiangOleg KruglovLarisa J GeskinOleg E AkilovPublished in: The British journal of dermatology (2022)
Six out of 12 Sézary patients shared one clonotype (TRAV13-1*01-TRAJ49*01-TRBV20-1*01-TRBJ2-3*01). TRBV20-1*01 (also known as Vb2) that binds toxic shock syndrome toxin-1 was utilized by Sézary cells among half of the cohort, which would be expected for a common unifying origin.
Keyphrases
- end stage renal disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- escherichia coli
- chronic kidney disease
- single cell
- peritoneal dialysis
- high frequency
- cell therapy
- cell cycle arrest
- dendritic cells
- immune response
- oxidative stress
- patient reported outcomes
- stem cells
- endoplasmic reticulum stress
- cell proliferation
- signaling pathway