The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis.

Ming ZhaoSeon-Yle KoI Ross GarrettGregory R MundyGloria E GutierrezJames R Edwards

Published in: British journal of pharmacology (2018)

These findings suggest a new mechanism of action in bone remodelling and the ageing skeleton, where RSV positively impacts bone homeostasis via SIRT1 activation of BMP2.

Keyphrases

bone mineral density
bone regeneration
bone loss
postmenopausal women
mesenchymal stem cells
oxidative stress
type diabetes
body composition
high fat diet induced
adipose tissue
protein protein
amino acid
respiratory syncytial virus