Medicinal Plants from Brazilian Cerrado: Antioxidant and Anticancer Potential and Protection against Chemotherapy Toxicity.
José Tarcisio G CarvalhoDébora da Silva BaldiviaDaniel Ferreira LeiteLaura Costa Alves de AraújoPriscilla Pereira de Toledo EspindolaKatia Ávila AntunesPaola Dos Santos da RochaKely de Picoli SouzaEdson Lucas Dos SantosPublished in: Oxidative medicine and cellular longevity (2019)
The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained from medicinal plants from the Brazilian Cerrado and the cell death profile induced by each of these extracts in malignant cells. Next, we describe the capacity of other medicinal plants from the Cerrado to protect against chemotherapy-induced cell toxicity. Finally, we focus on recent insights into the cell death profile induced by extracts from Cerrado plants and perspectives for future therapeutic approaches.
Keyphrases
- cell death
- cell cycle arrest
- oxidative stress
- induced apoptosis
- chemotherapy induced
- cancer therapy
- pi k akt
- signaling pathway
- endoplasmic reticulum stress
- single cell
- stem cells
- cell therapy
- risk assessment
- radiation therapy
- human health
- squamous cell carcinoma
- cell proliferation
- bone marrow
- current status
- climate change