Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells.

Kaitao ZhaoFangteng GuoJingjing WangYouquan ZhongJunzhu YiYan TengZaichao XuLi ZhaoAixin LiZichen WangXinwen ChenXiaoming ChengYuchen Xia

Published in: Hepatology (Baltimore, Md.) (2022)

Our results imply that the disassembly of cytoplasmic HBV nucleocapsids is restricted in murine hepatic cells. Overcoming this limitation may help to establish an HBV infection mouse model.

Keyphrases

hepatitis b virus
induced apoptosis
liver failure
cell cycle arrest
mouse model
endoplasmic reticulum stress
cell death
signaling pathway
oxidative stress
pi k akt