Proinflammatory plasticity towards Th17 paradigm of regulatory T cells consistent with elevated prevalence of TGFBR2 variants in elderly patients with primary immune thrombocytopenia.

Jingjing CaoYanxia ZhanLili JiPu ChenLuya ChengFeng LiXibing ZhuangZhihui MinLihua SunFanli HuaHao ChenBoting WuYunfeng Cheng

Published in: BMC immunology (2023)

Our findings revealed additional aberrations of Treg proinflammatory plasticity in elderly primary ITP patients, and highlighted the potential role of Treg dysfunction and senescence in the pathogenesis and management among these patients.

Keyphrases

regulatory t cells
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
dna damage
risk factors
peritoneal dialysis
endothelial cells
immune response
copy number
dna methylation
stress induced
community dwelling
gene expression
dendritic cells
genome wide