Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation.

Laura K GodfreyJan ForsterSven-Thorsten LiffersChristopher SchröderJohannes KösterLeonie HenschelKerstin U LudwigDavid LähnemannMarija Trajkovic-ArsicDiana BehrensAldo ScarpaRita T LawlorKathrin E WitzkeBarbara SitekSteven A JohnsenSven RahmannBernhard HorsthemkeMichael ZeschnigkJens T Siveke

Published in: Clinical epigenetics (2024)

Overall, the concept of acquired therapy resistance as a result of the expansion of a single cell clone with epigenetic plasticity sheds light on genetic, epigenetic and phenotypic patterns during evolvement of treatment resistance in a tumor with high adaptive capabilities and provides potential for reversion through epigenetic targeting.

Keyphrases

dna methylation
gene expression
single cell
signaling pathway
genome wide
single molecule
high throughput
circulating tumor
risk assessment
cell proliferation
bone marrow
combination therapy
climate change
replacement therapy
nucleic acid