Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells.
Núbia Sabrina MartinsThais Fernanda de Campos Fraga-SilvaGiseli Furlan CorreaMèdéton Mahoussi Michaël BokoLeandra Naira Zambelli RamalhoDébora Munhoz RodriguesJuliana Issa HoriDiego Luis CostaJairo Kenupp BastosVania Luiza Deperon BonatoPublished in: Pharmaceutics (2021)
Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma. In a previous study, our group showed that green propolis treatment reduced airway inflammation and mucus secretion in an ovalbumin (OVA)-induced asthma model and resulted in increased regulatory T cells (Treg) and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) frequencies in the lungs, two leukocyte populations that have immunosuppressive functions. In this study, we evaluated the anti-inflammatory effects of artepillin C (ArtC), the major compound of green propolis, in the context of allergic airway inflammation. Our results show that ArtC induces in vitro differentiation of Treg cells and monocytic MDSC (M-MDSC). Furthermore, in an OVA-induced asthma model, ArtC treatment reduced pulmonary inflammation, eosinophil influx to the airways, mucus and IL-5 secretion along with increased frequency of M-MDSC, but not Treg cells, in the lungs. Using an adoptive transfer model, we confirmed that the effect of ArtC in the reduction in airway inflammation was dependent on M-MDSC. Altogether, our data show that ArtC exhibits an anti-inflammatory effect and might be an adjuvant therapy for allergic asthma.
Keyphrases
- induced apoptosis
- anti inflammatory
- allergic rhinitis
- cell cycle arrest
- regulatory t cells
- chronic obstructive pulmonary disease
- oxidative stress
- cell death
- endoplasmic reticulum stress
- stem cells
- signaling pathway
- early stage
- diabetic rats
- cell proliferation
- pulmonary hypertension
- electronic health record
- drug induced
- air pollution
- stress induced
- peripheral blood
- data analysis
- genetic diversity