A comparison of MyPKFiT and WAPPS-Hemo as dosing tools for optimizing prophylaxis in patients with severe haemophilia A treated with Octocog alfa.

Alexandros ArvanitakisErik Berntorp Jan Astermark

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2021)

MyPKFiT and WAPPS-Hemo provided similar half-life estimations for Octocog alfa independent of the FVIII assay used. The doses suggested by WAPPS-Hemo to reach specific troughs were overall lower, which may have implications for treatment optimization.

Keyphrases

replacement therapy
high throughput
smoking cessation