Location of Recurrences after Trimodality Treatment for Glioblastoma with Respect to the Delivered Radiation Dose Distribution and Its Influence on Prognosis.
Nika GuberinaFlorian PadebergChristoph PöttgenMaja GuberinaLazaros LazaridisRamazan JabbarliCornelius DeuschlKen HerrmannTobias BlauKarsten H WredeKathy KeyvaniBjörn SchefflerJörg HenseJulian Philipp LayerMartin GlasUlrich SureMartin StuschkePublished in: Cancers (2023)
Two-thirds of recurrences were observed within a 10 mm margin around the GTV. Smaller margins reduce normal brain radiation exposure allowing for more extensive salvage radiation therapy options in case of recurrence. Prospective trials using margins smaller than 20 mm around the GTV are warranted.