How Did We End Up Using a Quadruple Guided Therapy Combining At Least Two Antibiotics with a PPI to Eradicate Helicobacter pylori ?

Since the discovery of Helicobacter pylori , and even if the species is frequently susceptible to many antibiotics in vitro , only six of them (amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin) and bismuth salts could be considered as effective in vivo to eliminate H pylori and have been used in recommended eradication treatments [...].