Conventional MRI-based subchondral trabecular biomarkers as predictors of knee osteoarthritis progression: data from the Osteoarthritis Initiative.
Farhad PishgarAli GuermaziFrank W RoemerThomas M LinkShadpour DemehriPublished in: European radiology (2020)
• Despite the lower spatial resolution than what is required to accurately study the subchondral trabecular microstructures, the "conventional" IW MRI sequences may retain adequate information that allows quantification of trabecular microstructure biomarkers. • Subchondral trabecular biomarkers obtained from "conventional" IW MRI sequences (i.e., cTbTh, cTbSp, and cBV/TV) are reliable and valid measures of trabecular microstructure changes compared to those from "apparent" trabecular biomarkers (from the FISP MRI sequence) and peri-articular BMD (from DXA). • Increased trabecular thickness and bone-to-total ratio (cTbTh and cBV/TV, obtained from "conventional" IW MRI sequences) from baseline to 24-month visits may be associated with higher odds of knee OA pain progression over 48 months of follow-up.
Keyphrases
- bone mineral density
- knee osteoarthritis
- contrast enhanced
- postmenopausal women
- magnetic resonance imaging
- diffusion weighted imaging
- body composition
- magnetic resonance
- rheumatoid arthritis
- total knee arthroplasty
- white matter
- computed tomography
- healthcare
- chronic pain
- spinal cord injury
- big data
- health information