Ginsenoside Rg1 Ameliorates Pancreatic Injuries via the AMPK/mTOR Pathway in vivo and in vitro.
Jin ChenGuoping ZhuWenbo XiaoXiaosong HuangKewu WangYi ZongPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2023)
Our findings revealed that G-Rg1 exhibits strong anti-apoptosis ability in pancreatic tissues of type 1 diabetic mice and HG-induced RIN-m5F cells, and the mechanisms involved in activating AMPK and inhibiting mTOR-mediated autophagy, indicating that G-Rg1 may have the therapeutic and preventive potential for treating pancreatic injury in diabetic patients.
Keyphrases
- cell cycle arrest
- signaling pathway
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- oxidative stress
- skeletal muscle
- cell proliferation
- pi k akt
- gene expression
- diabetic rats
- high glucose
- protein kinase
- single cell
- risk assessment
- mouse model
- drug induced
- human health
- climate change
- endothelial cells
- single molecule