Transient Receptor Potential Ankyrin 1 (TRPA1) Modulation by 4-Hydroxynonenal (4-HNE) in Pancreatic Adenocarcinoma Cell Lines: Putative Roles for Therapies.
Florentina PiciuDan DomocosGabriela N ChiritoiuMarioara Chiritoiu-ButnaruMaria MerneaCezar Gabriel PopescuDragoș Paul MihaiBianca GălățeanuAriana HudițăAlexandru BabesDana CucuPublished in: Pharmaceuticals (Basel, Switzerland) (2024)
Our study brings new insights into the effects of 4-HNE, highlighting the activation of the TRPA1 channel, a druggable, putative target for PDAC-expressing tumors.