Combination of anti-CD25 antibody and poly I:C treatment in pregnant NOD mice may be used as 'pregnancy-related' type 1 diabetes model.

Akira ShimadaKyoko TodaIkuo InoueTaketo YamadaYoichi Oikawa

Published in: Journal of diabetes investigation (2022)

We describe the use of anti-CD25 antibody to reduce regulatory T cells and poly I:C as a Toll-like receptor 3 stimulator to mimic viral infection in a pregnant NOD mouse, which can be used as a model of 'pregnancy-related' type 1 diabetes.

Keyphrases

toll like receptor
type diabetes
regulatory t cells
nuclear factor
pregnant women
preterm birth
inflammatory response
glycemic control
dendritic cells
cardiovascular disease
immune response
pregnancy outcomes
insulin resistance
nk cells
innate immune
high fat diet induced
smoking cessation
replacement therapy