Tumor Pre-Targeting System Using Streptavidin-Expressing Bacteria.

Seong-Young KwonSung-Hwan YouJin Hee ImDinh-Huy NguyenDong-Yeon KimAyoung PyoGeun-Joong KimHee-Seung BomYeongjin HongJung-Joon Min

Published in: Molecular imaging and biology (2024)

We successfully engineered tumor-targeting bacteria carrying a recombinant plasmid expressing mSA, which was targeted to, and expressed in, tumor tissues. These data demonstrate the potential of this novel tumor pre-targeting system when combined with biotinylated imaging probes or therapeutic agents.

Keyphrases

cancer therapy
escherichia coli
gene expression
high resolution
small molecule
electronic health record
crispr cas
drug delivery
cell free
data analysis
wild type