Supplementation with dietary omega-3 PUFA mitigates fetal brain inflammation and mitochondrial damage caused by high doses of sodium nitrite in maternal rats.
Jingchi SunWeishe ZhangPublished in: PloS one (2022)
Sodium nitrite exposure during pregnancy could cause brain damage in fetal rats. PUFA ω-3 might help alleviate brain inflammation, oxidative stress, and mitochondrial damage, possibly through the NRF1/HMOX1 signaling pathway. In conclusion, appropriately reducing sodium nitrite exposure and increasing PUFA omega-3 intake during pregnancy may benefit fetal brain development. These findings could further our understanding of nutrition and health during pregnancy.
Keyphrases
- oxidative stress
- resting state
- white matter
- induced apoptosis
- dna damage
- nitric oxide
- diabetic rats
- ischemia reperfusion injury
- signaling pathway
- functional connectivity
- cerebral ischemia
- healthcare
- public health
- mental health
- physical activity
- multiple sclerosis
- epithelial mesenchymal transition
- cell proliferation
- risk assessment
- climate change
- weight gain