Ischemic Postconditioning Alleviates Intestinal Ischemia-Reperfusion Injury by Enhancing Autophagy and Suppressing Oxidative Stress through the Akt/GSK-3β/Nrf2 Pathway in Mice.

Rong ChenYun-Yan ZhangJia-Nan LanHui-Min LiuWei LiYang WuYan LengLing-Hua TangJia-Bao HouQian SunTao SunZi ZengZhong-Yuan Xia Qing-Tao Meng

Published in: Oxidative medicine and cellular longevity (2020)

Our study indicates that IPO can ameliorate IIR injury by evoking autophagy, activating Akt, inactivating GSK-3β, and activating Nrf2. These findings may provide novel insights for the alleviation of IIR injury.β/Nrf2 pathway.

Keyphrases

signaling pathway
oxidative stress
ischemia reperfusion injury
pi k akt
induced apoptosis
dna damage
diabetic rats
cerebral ischemia
cell death
heat shock
high fat diet induced
wild type