First Trimester Contingent Screening for Aneuploidies with Cell-Free Fetal DNA in Singleton Pregnancies - a Swiss Single Centre Experience.

Alice ProtoFabienne TrottmannSophie SchneiderSofia AmylidiFlorent BadiquéLorenz RischDaniel SurbekLuigi RaioBeatrice Mosimann

Published in: Geburtshilfe und Frauenheilkunde (2024)

Most women choose cffDNA or invasive testing as second tier according to national guidelines. Despite the delay associated with cffDNA testing after FCTS, 75% of all trisomy 21 are still diagnosed in the first trimester with this contingent screening model.

Keyphrases

cell free
circulating tumor
preterm birth
gestational age
pregnancy outcomes
polycystic ovary syndrome
type diabetes
pregnant women
single molecule
clinical practice
body mass index
adipose tissue
metabolic syndrome
cervical cancer screening
nucleic acid