The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy.
Joost BrinksElon H C Van DijkSzymon M KiełbasaHailiang MeiIsa van der VeenHendrika A B PetersHetty C M SipsRobbert G E NotenboomPaulus H A QuaxCamiel J F BoonOnno C MeijerPublished in: The Journal of clinical endocrinology and metabolism (2021)
The glucocorticoid receptor predominantly mediates the response to cortisol in human CECs. Interindividual differences are an important determinant regarding the cortisol response in human cultured CECs, whereas intrinsic sex differences appear less pronounced. The marked response of particular target genes in endothelial cells to cortisol, such as ZBTB16, warrants further investigation into their potential role in the pathophysiology of CSC and other vascular conditions.