Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice.

Simranpreet KaurAnuj SehgalAndy C WuSusan M MillardLena BatoonCheyenne J SandrockMichelle Ferrari-CestariJean-Pierre LevesqueDavid A HumeLiza J RaggattAllison R Pettit

Published in: Journal of hematology & oncology (2021)

These results indicate that CSF1-Fc conditioning could represent a therapeutic strategy to overcome poor HSC mobilisation and subsequently improve HSC transplantation outcomes.

Keyphrases

hematopoietic stem cell
type diabetes
metabolic syndrome
cerebrospinal fluid
bone marrow
weight loss