Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model.

Wen-Kai ChenLin-Juan FengQiao-Dan LiuQing-Feng KePei-Ya CaiPei-Ru ZhangLi-Quan CaiNian-Lai HuangWen-Ping Lin

Published in: Journal of neuroinflammation (2020)

Our study reveals for the first time that LRCH1 serves as a negative regulator of microglia-mediated neuroinflammation after SCI and provides clues for developing novel therapeutic approaches against SCI.

Keyphrases

spinal cord injury
neuropathic pain
spinal cord
inflammatory response
lipopolysaccharide induced
traumatic brain injury
lps induced
cognitive impairment
oxidative stress
blood brain barrier