Quantitative proteomic analysis of cerebrospinal fluid of women newly diagnosed with multiple sclerosis.
Eliska JankovskaDenisa LipcseyovaMichaela SvrdlikovaMiluse PavelcovaEva Kubala HavrdovaKarel HoladaJiri PetrakPublished in: The International journal of neuroscience (2020)
Our data confirm differential abundance of several previously proposed protein markers, and provide indirect support for involvement of copper-iron disbalance in MS. Most importantly, we identified two new differentially abundant CSF proteins that seem to be directly connected with myelin loss and axonal damage via TLR2 signaling and Nogo-receptor pathway in women newly diagnosed with RRMS.
Keyphrases
- newly diagnosed
- multiple sclerosis
- cerebrospinal fluid
- polycystic ovary syndrome
- white matter
- pregnancy outcomes
- toll like receptor
- cervical cancer screening
- mass spectrometry
- oxidative stress
- ms ms
- binding protein
- electronic health record
- high resolution
- inflammatory response
- immune response
- insulin resistance
- breast cancer risk
- big data
- protein protein
- type diabetes
- antibiotic resistance genes
- wastewater treatment
- machine learning
- nuclear factor
- optical coherence tomography
- optic nerve
- iron deficiency