Login / Signup

Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse.

Beverly Ann G BoyboyKenji Ichiyanagi
Published in: Mobile DNA (2024)
This study disclosed a number of genetic changes that have changed the histone acetylation levels during the evolution of mouse subspecies, a part of which is associated with gene expression changes. Insertions of even a very short L1 fragment can decrease the acetylation level in their neighboring regions and thereby have been counter-selected in gene-rich regions, which may explain a long-standing mystery of discrete genomic distribution of LINEs and SINEs.
Keyphrases
  • dna methylation
  • gene expression
  • copy number
  • genome wide
  • histone deacetylase