Matrix-assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke-reperfusion injury in mice.
Jasmine S H WangMoises Freitas-AndradeJohn F BechbergerChristian C NausKen K-C YeungShawn Narain WhiteheadPublished in: Rapid communications in mass spectrometry : RCM (2018)
Overall, the data reveals successful penetration of ZP1609 across the blood-brain barrier. The benefits of tissue acidification in the enhancement of detection sensitivity for low-abundance peptides were demonstrated. MALDI-IMS has been shown to be a useful technique in the direct detection of drugs within intact brain tissue sections.
Keyphrases
- mass spectrometry
- cerebral ischemia
- high resolution
- loop mediated isothermal amplification
- real time pcr
- label free
- liquid chromatography
- atrial fibrillation
- acute myocardial infarction
- electronic health record
- big data
- white matter
- capillary electrophoresis
- gas chromatography
- high fat diet induced
- heart failure
- adipose tissue
- insulin resistance
- brain injury
- machine learning
- blood brain barrier
- amino acid
- combination therapy
- acute coronary syndrome
- artificial intelligence
- left ventricular
- skeletal muscle
- microbial community
- wild type
- deep learning
- fluorescence imaging
- tandem mass spectrometry
- functional connectivity