Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality.

Mitsutoshi YamadaSuguru SatoReina OokaKazuhiro AkashiAkihiro NakamuraKenji MiyadoHidenori AkutsuMamoru Tanaka

Published in: Reproductive medicine and biology (2020)

The maternal genome is fundamentally compatible with different mitochondrial genotypes, and vertical inheritance is not required for normal mitochondrial function. Unresolved questions regarding mtDNA genetic drift can be addressed by basic research using MRT.

Keyphrases

genome wide
mitochondrial dna
oxidative stress
copy number
endothelial cells
dna methylation
birth weight
pregnancy outcomes
gene expression
physical activity
preterm birth