TRIM26 inhibits clear cell renal cell carcinoma progression through destabilizing ETK and thus inactivation of AKT/mTOR signaling.

Di ZhengJinzhuo NingHao DengYuan RuanFan Cheng

Published in: Journal of translational medicine (2024)

Our results have shown a novel mechanism by which TRIM26 hinders the advancement of ccRCC by binding to and destabilizing ETK, thus leading to the deactivation of AKT/mTOR signaling. TRIM26 shows promise as both a therapeutic target and prognostic biomarker for ccRCC patients.

Keyphrases

cell proliferation
end stage renal disease
signaling pathway
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
machine learning
artificial intelligence
deep learning