Extracellular vesicles originating from glioblastoma cells increase metalloproteinase release by astrocytes: the role of CD147 (EMMPRIN) and ionizing radiation.

Published in: Cell communication and signaling : CCS (2020)

The results support a tumor microenvironment-mediated role of CD147 in glioblastoma invasiveness, and reveal a prominent role for ionizing radiation in enhancing the effect. They provide an improved understanding of glioblastoma intercellular signaling in the context of radiotherapy, and identify pathways that can be targeted to reduce tumor invasiveness. Video abstract.

Keyphrases

induced apoptosis
early stage
cell cycle arrest
radiation therapy
genome wide
squamous cell carcinoma
locally advanced
single cell
cell death
radiation induced
gene expression
signaling pathway
drug delivery
cell proliferation