Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2).
Nicholas K BodmerRussell H KnutsenRobyn A RothRyan M CastileMichael D BrodtCarrie M GieraschThomas J BroekelmannMark A GibsonJeffrey A HaspelSpencer P LakeJeffrey R KoenitzerSteven L BrodyMatthew J SilvaRobert P MechamDavid M OrnitzPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2023)
Analysis of these mice show that LTBP2 has complex effects on development through direct effects on the extracellular matrix (ECM) or on signaling pathways that are known to regulate the ECM.