Iron Oxide Nanoparticles: Physicochemical Characteristics and Historical Developments to Commercialization for Potential Technological Applications.
Hossein EtemadiJenna K BuchananNadia G KandilePaul G PliegerPublished in: ACS biomaterials science & engineering (2021)
Iron oxide nanoparticles (IONPs) have gained increasing attention in various biomedical and industrial sectors due to their physicochemical and magnetic properties. In the biomedical field, IONPs are being developed for enzyme/protein immobilization, magnetofection, cell labeling, DNA detection, and tissue engineering. However, in some established areas, such as magnetic resonance imaging (MRI), magnetic drug targeting (MDT), magnetic fluid hyperthermia (MFH), immunomagnetic separation (IMS), and magnetic particle imaging (MPI), IONPs have crossed from the research bench, received clinical approval, and have been commercialized. Additionally, in industrial sectors IONP-based fluids (ferrofluids) have been marketed in electronic and mechanical devices for some time. This review explores the historical evolution of IONPs to their current state in biomedical and industrial applications.
Keyphrases
- iron oxide nanoparticles
- magnetic resonance imaging
- molecularly imprinted
- tissue engineering
- wastewater treatment
- heavy metals
- contrast enhanced
- high resolution
- computed tomography
- single cell
- working memory
- cancer therapy
- stem cells
- single molecule
- cell therapy
- climate change
- solid phase extraction
- cell free
- magnetic resonance
- bone marrow
- mass spectrometry
- label free
- circulating tumor cells