Afucosylated anti-EBOV antibody MIL77-3 engages sGP to elicit NK cytotoxicity.

Yuting ZhangMin ZhangHaiyan WuXiaonan WuHang ZhengJunjuan FengMianjing WangJing WangLonglong LuoHe XiaoChunxia QiaoXinying LiYuanqiang ZhengWeijin HuangYouchun WangYi WangJiannan FengGuojiang Chen

Published in: Journal of virology (2024)

. Our work here uncovers the potential harmful influence of this modification on host immune responses, especially for mAbs with cross-reactivity to secreted glycoproptein (sGP) (e.g., MIL77-3), and highlights it is necessary to evaluate the NK-stimulating activity of a fucosylated mAb engaged with sGP when a new candidate is developed.

Keyphrases

immune response
metal organic framework
solid phase extraction
nk cells
toll like receptor
dendritic cells
human health
inflammatory response
climate change