Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing.

Jennifer M GrantsChristina MayJosh BridgersShujun HuangSierra GillisBarbara MeissnerMerrill BoyleSusana Ben-NeriahStacy HungGerben DunsLaura HiltonAlina S GerrieMarco A MarraRobert KridelPeter J B SabatiniChristian SteidlDavid W ScottAly Karsan

Published in: Clinical chemistry (2024)

A targeted capture approach to IGHV SHM detection can be integrated into broader sequencing panels, allowing broad CLL prognostication in a single molecular assay.

Keyphrases

chronic lymphocytic leukemia
loop mediated isothermal amplification
cancer therapy
real time pcr
label free
single cell
high throughput
gene expression
dna methylation
cell free