Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach.

Pei Kun HeYu Yuan GaoFeng-Juan LyuJia Ning ChenYu Hu ZhangKun NieQing Xi ZhangRui HuangQing Rui DuanMan Li GuoZhi Hua LiuHe Ling HuangGui Xian MaLi-Juan Wang Li Min Wang

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

This study demonstrated that Idebenone exerts its anti-PD effects by enhancing autophagy and clearance of α-synuclein, thus providing a theoretical and experimental basis for Idebenone therapy against PD.

Keyphrases

signaling pathway
cell death
cell proliferation
oxidative stress
stem cells
cell therapy