Emerging therapeutic targets and preclinical models for severe asthma.
Izabela GalvãoRichard Y KimSijie ShenKurtis F BuddenAngélica T VieiraPhilip Michael HansbroPublished in: Expert opinion on therapeutic targets (2020)
Increasing the understanding of disease-causing mechanisms in severe asthma may lead to the identification of novel therapeutic targets and the development of more effective therapies. Intense research interest into investigating the pathophysiological mechanisms of severe asthma has driven the development and interrogation of a myriad of mouse models that aim to replicate hallmark features of severe asthma in humans.