Optimal pathological response after neoadjuvant chemotherapy for muscle-invasive bladder cancer: results from a global, multicentre collaboration.
Praful RaviGregory R PondLeonidas N DiamantopoulosChristopher SuAjjai AlvaRohit K JainWilliam Paul SkeltonSumati GuptaJonathan D TwardKathleen M OlsonParminder SinghCamilla M GrunewaldGuenter NiegischJae-Lyun LeeAndrea GallinaMarco BandiniAndrea NecchiMatthew MossanenBradley A McGregorCatherine CurranPetros GrivasGuru P SonpavdePublished in: BJU international (2021)
We propose that optimal pathological response after NAC be defined as attainment of ypT0N0/ypTisN0 at RC. Patients with ypTaN0 or ypT1N0 disease (with or without Tis) at RC displayed a significantly higher risk of recurrence and may be candidates for trials investigating adjuvant therapy.