HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients.
Yasser S BasmaeilDana AlgudiriReem AlenziAbdullah Al SubayyilAyodele AlaiyaTanvir KhatlaniPublished in: Stem cell research & therapy (2020)
We hereby show for the first time that loss of function of stem cells/stromal cells isolated from the patients with preeclampsia may contribute towards the disease exacerbation. Our results suggest that HMOX1 may be partially responsible for the loss of functionality in PE-DBMSCs and contribute significantly towards the pathophysiology of preeclampsia. However, further investigation is required to decipher its exact role in the development and onset of the disorder.
Keyphrases
- stem cells
- early onset
- mesenchymal stem cells
- end stage renal disease
- ejection fraction
- bone marrow
- chronic kidney disease
- newly diagnosed
- chronic obstructive pulmonary disease
- pregnancy outcomes
- peritoneal dialysis
- prognostic factors
- umbilical cord
- cell therapy
- pregnant women
- density functional theory
- molecular dynamics
- acute respiratory distress syndrome
- patient reported