Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN).
Wendy Chiawen HsiaoYimei LiKelly GetzLusha CaoEdward KrauseMark RamosJudy LeeMaria Monica GramatgesKaren R RabinMichael E ScheurerRichard AplencMichelle DenburgTamara P MillerPublished in: Pediatric blood & cancer (2023)
Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.
Keyphrases
- acute myeloid leukemia
- acute kidney injury
- electronic health record
- chronic kidney disease
- end stage renal disease
- cardiac surgery
- allogeneic hematopoietic stem cell transplantation
- risk factors
- clinical decision support
- bone marrow
- liver failure
- adverse drug
- young adults
- drug induced
- respiratory failure
- type diabetes
- stem cells
- big data
- metabolic syndrome
- aortic dissection
- acute lymphoblastic leukemia
- machine learning
- dendritic cells
- immune response
- extracorporeal membrane oxygenation
- cell therapy
- acute respiratory distress syndrome
- artificial intelligence
- skeletal muscle
- glycemic control