D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects.

Hao LiuRanli GuYuan ZhuXiaomin LianSiyi WangXuenan LiuZhang PingYunsong LiuYongsheng Zhou

Published in: Therapeutic advances in chronic disease (2020)

D-mannose attenuated bone loss induced by senility and estrogen deficiency in mice, and this effect may be mediated by D-mannose-induced proliferation of regulatory T cells and gut microbiota-dependent anti-inflammatory effects.

Keyphrases

bone loss
regulatory t cells
cell proliferation
high fat diet induced
dendritic cells
signaling pathway
type diabetes
estrogen receptor
adipose tissue
immune response
replacement therapy