DNA Nanomachines for Identifying Cancer Biomarkers in Body Fluids and Cells.
Zaizai DongXinying XueHailun LiangJingjiao GuanLingqian ChangPublished in: Analytical chemistry (2020)
Identifying molecular biomarkers promises to significantly improve the accuracy in cancer diagnosis at its early stage. DNA nanomachines, which are designable and switchable nanostructures made of DNA, show broad potential to detect tumor biomarkers with noninvasive, inexpensive, highly sensitive, and highly specific advantages. This Feature summarizes the recent DNA nanomachine-based platforms for the early detection of cancer biomarkers, both from body fluids and in cells.
Keyphrases
- papillary thyroid
- circulating tumor
- single molecule
- cell free
- early stage
- induced apoptosis
- squamous cell
- cell cycle arrest
- machine learning
- squamous cell carcinoma
- cell death
- childhood cancer
- endoplasmic reticulum stress
- climate change
- radiation therapy
- circulating tumor cells
- cell proliferation
- rectal cancer
- locally advanced
- fluorescent probe