Diagnosing enterovirus meningitis via blood transcriptomics: an alternative for lumbar puncture?
Esther BartholomeusNicolas De NeuterAnnelies LemayLuc PattynDavid TuerlinckxDavid WeynantsKoen Van LedeGerlant van BerlaerDominique BulckaertTine BoiyAnn Vander AuweraMarc RaesDimitri Van der LindenHelene VerhelstSusanne Van SteijnTijl JonckheerJoke DehoorneRik JoosHilde JansensArvid SulsPierre Van DammeKris LaukensGeert MortierPieter MeysmanBenson OgunjimiPublished in: Journal of translational medicine (2019)
Enteroviral meningitis has an innate immunity signature with type 1 interferons as key players. Our classifier, based on blood host transcriptomic profiles of different meningitis cases, is a possible strong alternative for diagnosing enteroviral meningitis.