LPS-Induced Mitochondrial Dysfunction Reduces Oocyte Maturation and Developmental Competence of Buffalo Embryos via ROS Mediated TLR4 Signalling.

Sujata JinagalRavi DuttManinder SharmaMeeti PunethaSheetal SainiSwati ThakurSuman ChaudharyPradeep KumarPrem Singh YadavTirth Kumar DattaDharmendra Kumar

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)

The deleterious effects of LPS are mediated through ROS generation, which triggers inflammatory processes via the TLR4 pathway and impairs oocyte maturation and subsequent embryonic development.

Keyphrases

inflammatory response
lps induced
toll like receptor
dna damage
cell death
reactive oxygen species
immune response
oxidative stress
nuclear factor