Fluorescent Molecular Rotors for Viscosity Sensors.
Seung-Chul LeeJeongyun HeoHee Chul WooJi-Ah LeeYoung Hun SeoChang-Lyoul LeeSehoon KimO-Pil KwonPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push-pull type π-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed.
Keyphrases
- living cells
- quantum dots
- label free
- photodynamic therapy
- single molecule
- structure activity relationship
- magnetic resonance
- high throughput
- fluorescent probe
- circulating tumor cells
- single cell
- low cost
- energy transfer
- magnetic resonance imaging
- contrast enhanced
- climate change
- cancer therapy
- computed tomography
- human health
- metal organic framework