Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study.
Robert Carreras-TorresMattias JohanssonPhilip C HaycockKaitlin H WadeCaroline L ReltonRichard M MartinGeorge Davey SmithDemetrius AlbanesMelinda C AldrichAngeline AndrewSusanne M ArnoldHeike BickeböllerStig E BojesenHans BrunnströmJonas ManjerIrene BrüskeNeil E CaporasoChu ChenDavid C ChristianiW Jay ChristianJennifer A DohertyEric J DuellJohn K FieldMichael P A DaviesMichael W MarcusGary E GoodmanKjell GrankvistAage HaugenYun-Chul HongLambertus A L M KiemeneyErik H F M van der HeijdenPeter KraftMikael B JohanssonStephen LamMaria Teresa LandiPhilip LazarusLoïc Le MarchandGeoffrey LiuOlle MelanderSungshim L ParkGad RennertAngela RischEric B HauraGhislaine SceloDavid ZaridzeAnush MukeriyaMilan SavićJolanta LissowskaBeata SwiatkowskaVladimir JanoutIvana HolcatovaDana MatesMatthew B SchabathHongbing ShenAdonina TardonMarion Dawn TearePenella WollMing-Sound TsaoXifeng WuJian-Min YuanRayjean J HungChristopher I AmosJames D McKayPaul BrennanPublished in: PloS one (2017)
Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.