Upregulated circPDK1 Promotes RCC Cell Migration and Invasion by Regulating the miR-377-3P-NOTCH1 Axis in Renal Cell Carcinoma.

Zhenlin HuangYinghui DingLu ZhangSiyuan HeZhankui JiaChaohui GuTao WangHao LiXiang LiZhibo JinYafei DingJinjian Yang

Published in: OncoTargets and therapy (2020)

CircPDK1 is aberrantly expressed in RCC and promotes the metastasis of RCC cells mainly through sponging miR-377-3P and reducing its negative regulation of NOTCH1. Thus, circPDK1 may act as a therapeutic target and biomarker for RCC.

Keyphrases

renal cell carcinoma
induced apoptosis
cell proliferation
single cell
cell cycle arrest
cell therapy
stem cells
endoplasmic reticulum stress
mesenchymal stem cells
cell death
bone marrow