The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes.
Lina ReslanNour YoussefCelina F BoutrosAia Assaf-CasalsDanielle FayadSarah KhafajaFata AklMarc FinianosAmena A RizkRouba ShakerAlissar ZaghloutMireille LteifBassam El HafiMohammad Bahij MoumnehRita FeghaliSoha GhanemTamima JisrGilbert KarayakoupoglouMalak NaboulsiMonzer HamzeSalam SamadElie KhouryRicardo SarrafMarwan OsmanElie Bou RaadHadi El AminIbrahim AbadiHicham AbdoMarwan ChedidFatima ChamseddineAngelique BarakatMohammad HoumaniAntoine HaddadGeorges Abdel NourJacques E MokhbatZiad DaoudMohamad El-ZaatariElie Salem SokhnNada GhosnWalid AmmarRanda HamadehGhassan M MatarGeorge F ArajGhassan S DbaiboPublished in: Expert review of vaccines (2022)
PCVs substantially impacted IPD and AMR in vaccinated and unvaccinated populations despite an increase in mortality driven by NVT. Broadening the recommendation of vaccination to include older age-groups, using higher valency vaccines, and implementing stringent antimicrobial stewardship are likely to further impact the burden of IPD.