Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF).
Emmanuel EkanemVivek Y ReddyBoris SchmidtTobias ReichlinKars NevenAndreas MetznerJim HansenYuri BlaauwPhilippe MauryThomas ArentzPhilipp SommerAnte AnićFrederic AnselmeSerge BovedaTom DenekeStephan WillemsPepijn van der VoortRoland TilzMoritoshi FunasakoDaniel ScherrReza WakiliDaniel StevenJosef KautznerJohan VijgenPierre JaisJan PetruJulian ChunLaurent RotenAnna FütingAndreas RilligBart A MulderArne JohannessenAnne RollinHeiko LehrmannChristian SohnsZrinka JurisicArnaud SavoureStephanes CombesKarin NentwichMelanie GunawardeneAlexandre OussBettina KirsteinMartin ManningerJan Eric BohnenArian SultanPetr PeichlPieter KoopmanNicolas DervalMohit K TuragamPetr Neuzilnull nullPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)
In a large cohort of unselected patients, PFA was efficacious for PVI, and expressed a safety profile consistent with preferential tissue ablation. However, the frequency of 'generic' catheter complications (tamponade, stroke) underscores the need for improvement.