Ultra-low carbon dioxide partial pressure improves the galactosylation of a monoclonal antibody produced in Chinese hamster ovary cells in a bioreactor.
Chen WangJiaqi WangMin ChenLi FanLiang ZhaoWen-Song TanPublished in: Biotechnology letters (2018)
In the bioreactor culture processes, ultra-low pCO2 demonstrated a positive effect on mAb galactosylation.