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Ultra-low carbon dioxide partial pressure improves the galactosylation of a monoclonal antibody produced in Chinese hamster ovary cells in a bioreactor.

Chen WangJiaqi WangMin ChenLi FanLiang ZhaoWen-Song Tan
Published in: Biotechnology letters (2018)
In the bioreactor culture processes, ultra-low pCO2 demonstrated a positive effect on mAb galactosylation.
Keyphrases
  • monoclonal antibody
  • carbon dioxide
  • wastewater treatment
  • induced apoptosis
  • high resolution
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell proliferation
  • pi k akt