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Postmenopausal Androgen Metabolism and Endometrial Cancer Risk in the Women's Health Initiative Observational Study.

Kara A MichelsLouise A BrintonNicolas WenstzensenKathy PanChu ChenGarnet L AndersonRuth M PfeifferXia XuThomas E RohanBritton Trabert
Published in: JNCI cancer spectrum (2019)
We identified increased risks for endometrial cancer with the highest levels of adrenal androgens and high levels of estrogens relative to these androgens. As adrenal androgens can be aromatized to estrogens, this suggests androgens likely influence endometrial carcinogenesis via estrogen metabolism.
Keyphrases
  • endometrial cancer
  • healthcare
  • public health
  • polycystic ovary syndrome
  • human health
  • breast cancer risk
  • mental health
  • risk assessment
  • bone mineral density
  • pregnancy outcomes
  • insulin resistance
  • health promotion