Innate immune responses are increased in children with acute asthma exacerbation.
Shahid I SheikhMariah EisnerJoshua WalumKathryn HeyobAiman Q KhanBrandon LewisMitchell GraysonBenjamin KoppKaren McCoyRodney D BrittPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2024)
In acute asthma exacerbation, innate immune pathways remained increased while adaptive immune responses related to T helper cells are blunted and are independent of trigger or asthma severity. Our novel findings highlight the need to identify new therapies to target persistent innate immune responses to improve outcomes in acute asthma.
Keyphrases
- chronic obstructive pulmonary disease
- innate immune
- immune response
- lung function
- respiratory failure
- allergic rhinitis
- liver failure
- dendritic cells
- induced apoptosis
- drug induced
- toll like receptor
- type diabetes
- aortic dissection
- regulatory t cells
- intensive care unit
- inflammatory response
- signaling pathway
- endoplasmic reticulum stress
- skeletal muscle
- glycemic control
- mechanical ventilation