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50 Hz magnetic field influences caspase-3 activity and cell cycle distribution in ionizing radiation exposed SH-SY5Y neuroblastoma cells.

Valtteri NieminenMaria-Viola MartikainenSaija KalliomäkiTuomas VirénJan SeppäläJukka JuutilainenJonne NaaralaJukka Luukkonen
Published in: International journal of radiation biology (2024)
Only the 500 µT magnetic flux density affected SH-SY5Y cells significantly. The effects were small but may nevertheless help to understand how MFs modify the effects of ionizing radiation. The increase in caspase-3 activity may not reflect effects on apoptosis, as no changes were observed in the subG1 phase of the cell cycle. In contrast to some earlier findings, 50 Hz MF exposure after ionizing radiation was not less effective than MF treatment given prior to ionizing radiation.
Keyphrases
  • cell cycle
  • induced apoptosis
  • cell cycle arrest
  • cell death
  • endoplasmic reticulum stress
  • cell proliferation
  • oxidative stress
  • signaling pathway
  • pi k akt
  • magnetic resonance
  • computed tomography
  • smoking cessation