PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.

Linglu JiaDongfang LiYa-Nan WangDongjiao ZhangXin Xu

Published in: Journal of translational medicine (2023)

PSAT1 is a potential important regulator of the osteogenic lineage differentiation of PDLSCs through the ATF4/PSAT1/Akt/GSK3β/β-catenin signalling pathway. PSAT1 could be a candidate gene modification target for enhancing PDLSCs-based bone regeneration.

Keyphrases

signaling pathway
cell proliferation
stem cells
bone regeneration
mesenchymal stem cells
epithelial mesenchymal transition
transcription factor
pi k akt
bone marrow
endoplasmic reticulum stress
single cell
copy number
gene expression
cell fate